Golam Azam1*, Shahinul Alam2,
Abdullah Saeed Khan3, Rubayat Sheik Giasuddin4, Mobin
Khan5
1Associate Professor, Department of
Gastrointestinal, Hepatobiliary and Pancreatic Disorders (GHPD), BIRDEM General
Hospital, Shahbagh, Dhaka, Bangladesh
2Associate Professor, Department of Hepatology,
Bangabandhu Sheikh Mujib Medical University, Shahbagh, Dhaka, Bangladesh
3Research Associate, The Liver Centre, Dhanmondi,
Dhaka, Bangladesh
4Assistant Professor, Department of Medicine, Anwer Khan Modern
Medical College, Dhaka, Bangladesh
5Professor and Director, The Liver Centre,
Dhanmondi, Dhaka, Bangladesh
*Address for Correspondence: Dr. Golam
Azam, Associate Professor Department of
Gastrointestinal, Hepatobiliary and Pancreatic Disorders (GHPD), BIRDEM General
Hospital, Shahbag, Dhaka- 1000, Bangladesh
ABSTRACT- Background: Viral hepatitis B and C can
lead to the end stage liver disease and diabetes mellitus is also a life-long
chronic disease. Simultaneous presences of both of these conditions lead to
synergistic detrimental outcome. So identification of diabetes mellitus at the
initial evaluation of a patient having chronic hepatitis B and C is essential.
Materials and methods: This study was designed as a retrospective
single center cross-sectional study. The association of viral hepatitis B and C
with diabetes mellitus was investigated at the Liver Centre Dhaka, Bangladesh
for a period of 12 years. HBsAg was tested for hepatitis B virus infection and
anti-HCV for hepatitis C virus infection. Demographic profile and biochemical
data were retrieved from records.
Results: A total of 29425 cases were
analyzed in the study [median age 31(19–95) years, 24615(84%) males]. HBsAg
positive were 27475 and hepatitis C were 1950. Patients with hepatitis C were
older than hepatitis B (p<0.001). Although previous history of jaundice was
similar in both infections but history of blood transfusion was more common
among hepatitis C patients (p<0.001). Analyzing different conditions of
liver disease, it was observed that hepatitis B virus infection was highly
responsible for acute hepatitis than hepatitis C (10.7% vs 1.1%) (p<0.001).
Chronic hepatitis was similar in rate (73.3% vs 59.9%). But in both conditions
of cirrhosis of liver like compensated and decompensated states, hepatitis C
virus was significantly responsible than the hepatitis B virus 24.7% vs 9.6%
(p<0.001) and 14.3% vs 6.4% (p<0.001) respectively. The most significant
finding was very higher rate of diabetes among hepatitis C which was 22.6%
while only 1.8% among hepatitis B virus infection (p<0.001).
Conclusion: Hepatitis C virus was
highly related with the presence of diabetes than hepatitis B.
Key-words- Diabetes mellitus, Prevalence, Hepatitis B
virus, Hepatitis C virus
