Navneet Omprakash Soni*
Centre for Research in Molecular Pharmacology,
Shramik coloney, Laxminagar, Sangli Maharashtra, India
*Address for Correspondence: Dr. Navneet
Omprakash Soni, Research scholar, Department of Pharmacology, Centre for Research
in Molecular Pharmacology, Maharashtra, India
ABSTRACT- Dialysis is the only mode
of available palliative therapeutic modality to patient with end stage of renal
disease. Diabetes is one of the foremost common causes of chronic renal disease
and affecting large number of diabetic patients. By many theory, hypothesis and
study are carried to understand the pathogenesis of Diabetic kidney disease or
complication of diabetes i.e. diabetic nephropathy (DN) and based on pathophysiology
many drugs and molecules are being developed targeting enzymes, intracellular
proteins, micro RNA, Receptor, channel etc. Genes (like NFE2L2, HD1, RPD3 etc.) responsible for
synthesis of transcription factor, proteins, enzymes and cytokine factors, intracellular
antioxidant factor all play vital role in pathophysiology of DN. Targeting
multiple genes, which play important role in pathophysiology of DN with
nanoparticle loaded with siRNA or drugs or combination will not only reduce
multiple drug and medication burden but also mitigate the disease faster and
with reversal of pathological changes with safety, if the challenges are met.
It is possible to target multiple genes, which play vital role in fibrosis and
extracellular matrix expansion which are key features of DN with biodegradable
particle. Each drug by unique mechanism specifically targeting protein,
enzymes, receptor, channel etc. mitigates the progress of DN and multiple drugs
are needed to inhibit the various mechanism. The approach of silencing the
multiple genes or delivering drugs inside the cell organelles with
biodegradable nanoparticles is novel, versatile and target specific to inhibit
the progress of DN and to reverse the pathological changes efficiently as
compared to drugs/molecules, if challenges of nanoparticle formulation are met. Based on the research till date and
available resource suggest it is possible to target multiple genes or protein
or enzymes or signaling molecules using biodegradable and biocompatible
nanoparticles (NP) loaded with siRNA
and drugs or combination of drug and siRNA.Key-words- Diabetic Nephropathy (DN), Proteinuria, Nanoparticles (NP), siRNA, Pathogenesis
